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"The UK tissue engineering research bias is towards biomedical and bioengineering applications which tackle long term disabling and chronically painful conditions. Major improvements would be possible across all areas of tumour/abdominal, neural, ocular, dermal and vascular surgery if suitable tissue engineered implants were available" (Foresight 2020, Healthcare report - Peckham 2000)
   
 
   
 
Tissue engineering only operates in reality where its component disciplines overlap. Interdisciplinary gaps to be bridged between cell biologists, surgeons, engineers and materials scientists cannot be overestimated. We must link stem-cell acquisition/selection and expansion with new knowledge on control of differentation and cell cuing. Process engineering involved in functional 3D tissue bioreactors, their dynamic controls, monitoring and regulation represent major challenges. Questions of tissue integration and rejection together with suitable bio-interactive and dynamic support materials continue to limit progress.
   
 
   
 
It is essential to set up a network now pulling together all the elements of UK tissue engineering. The initial linkage will be between a few focal centres with progressive growth.
   
 
   
  Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore HA7 4LP
tissue.eng@ucl.ac.uk
Administrator: Sally Brown

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